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In toxicology, the lowest published toxic dose (Toxic Dose Low, TD_Lo) is the lowest dosage per unit of bodyweight (typically stated in milligrams per kilogram) of a substance known to have produced signs of toxicity in a particular animal species. When quoting a TD_Lo, the particular species and method of administration (e.g. ingested, inhaled, intravenous) are typically stated.

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• Certain safety factor
• Lowest published lethal dose (LD_Lo)
• Median lethal dose (LD₅₀)